ea0065p279 | Neuroendocrinology | SFEBES2019
Pennington Kyla
, Klaus Kristel
, Fachim Helene
, Trischel Ksenia
, Dalton Caroline
, Reynolds Gavin
, Heald Adrian
Introduction: CACNA1C gene encodes the L-type voltage dependent calcium channels and its variants are associated with susceptibility to psychiatric disorders. We recently provided evidence of a genotype-by-environment interaction of the CACNA1C rs1006737 polymorphism, suggesting that the cortisol awakening response (CAR), an indicator of HPA-axis function, might be increased in non-risk allele carriers (GG) who have experienced childhood trauma (CT). In these...